Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.

TitleSurviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms.
Publication TypeJournal Article
Year of Publication2019
AuthorsYan, J, Bassler, BL
JournalCell Host Microbe
Volume26
Issue1
Pagination15-21
Date Published2019 Jul 10
ISSN1934-6069
Abstract

Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.

DOI10.1016/j.chom.2019.06.002
Alternate JournalCell Host Microbe
PubMed ID31295420
PubMed Central IDPMC6629468
Grant ListR01 GM065859 / GM / NIGMS NIH HHS / United States
R37 GM065859 / GM / NIGMS NIH HHS / United States