Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms. Author Jing Yan, Bonnie Bassler Publication Year 2019 Type Journal Article Abstract Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development. Keywords Biofilms, Anti-Bacterial Agents, Bacteria, Microbial Viability, Drug Tolerance, Drug Resistance, Bacterial Journal Cell Host Microbe Volume 26 Issue 1 Pages 15-21 Date Published 2019 Jul 10 ISSN Number 1934-6069 DOI 10.1016/j.chom.2019.06.002 Alternate Journal Cell Host Microbe PMCID PMC6629468 PMID 31295420 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML