Structural Insights into the Mechanism of Dynamin Superfamily Proteins. Author John Jimah, Jenny Hinshaw Publication Year 2019 Type Journal Article Abstract Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family. Keywords Animals, Humans, Protein Conformation, Dynamins Journal Trends Cell Biol Volume 29 Issue 3 Pages 257-273 Date Published 2019 Mar ISSN Number 1879-3088 DOI 10.1016/j.tcb.2018.11.003 Alternate Journal Trends Cell Biol PMCID PMC9623552 PMID 30527453 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML