Structural Insights into the Mechanism of Dynamin Superfamily Proteins.

TitleStructural Insights into the Mechanism of Dynamin Superfamily Proteins.
Publication TypeJournal Article
Year of Publication2019
AuthorsJimah, JR, Hinshaw, JE
JournalTrends Cell Biol
Date Published2019 Mar
KeywordsAnimals, Dynamins, Humans, Protein Conformation

<p>Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family.</p>

Alternate JournalTrends Cell Biol
PubMed ID30527453
PubMed Central IDPMC9623552
Grant ListZ01 DK060100 / ImNIH / Intramural NIH HHS / United States