Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.

TitleStructural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines.
Publication TypeJournal Article
Year of Publication2022
AuthorsHorwitz, SM, Blue, TC, Ambarian, JA, Hoshino, S, Seyedsayamdost, MR, Davis, KM
JournalRSC Chem Biol
Volume3
Issue4
Pagination420-425
Date Published2022/04/06
ISSN2633-0679
Abstract

Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.

DOI10.1039/d1cb00255d
Alternate JournalRSC Chem Biol
PubMed ID35441142
PubMed Central IDPMC8984913