| Title | Structural insights into inhibition of the drug target dihydroorotate dehydrogenase by bacterial hydroxyalkylquinolines. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Horwitz, SM, Blue, TC, Ambarian, JA, Hoshino, S, Seyedsayamdost, MR, Davis, KM |
| Journal | RSC Chem Biol |
| Volume | 3 |
| Issue | 4 |
| Pagination | 420-425 |
| Date Published | 2022 Apr 06 |
| ISSN | 2633-0679 |
| Abstract | <p>Hydroxyalkylquinolines (HAQs) are ubiquitious natural products but their interactions with associated protein targets remain elusive. We report X-ray crystal structures of two HAQs in complex with dihydroorotate dehydrogenase (DHODH). Our results reveal the structural basis of DHODH inhibition by HAQs and open the door to downstream structure-activity relationship studies.</p> |
| DOI | 10.1039/d1cb00255d |
| Alternate Journal | RSC Chem Biol |
| PubMed ID | 35441142 |
| PubMed Central ID | PMC8984913 |
| Grant List | R00 GM129460 / GM / NIGMS NIH HHS / United States |
