Structural Biology of the Major Facilitator Superfamily Transporters.

TitleStructural Biology of the Major Facilitator Superfamily Transporters.
Publication TypeJournal Article
Year of Publication2015
AuthorsYan, N
JournalAnnu Rev Biophys
Volume44
Pagination257-83
Date Published2015
ISSN1936-1238
KeywordsAnimals, Bacteria, Crystallography, X-Ray, History, 20th Century, History, 21st Century, Humans, Membrane Transport Proteins
Abstract

The ancient and ubiquitous major facilitator superfamily (MFS) represents the largest secondary transporter family and plays a crucial role in a multitude of physiological processes. MFS proteins transport a broad spectrum of ions and solutes across membranes via facilitated diffusion, symport, or antiport. In recent years, remarkable advances in understanding the structural biology of the MFS transporters have been made. This article reviews the history, classification, and general features of the MFS proteins; summarizes recent structural progress with a focus on the sugar porter family transporters exemplified by GLUT1; and discusses the molecular mechanisms of substrate binding, alternating access, and cotransport coupling.

DOI10.1146/annurev-biophys-060414-033901
Alternate JournalAnnu Rev Biophys
PubMed ID26098515
Grant List / / Howard Hughes Medical Institute / United States