Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect.

TitleStructural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect.
Publication TypeJournal Article
Year of Publication2022
AuthorsJiang, X, Yan, N, Deng, D, Yan, C
JournalIUBMB Life
Volume74
Issue12
Pagination1180-1199
Date Published2022 Dec
ISSN1521-6551
KeywordsFermentation, Glucose, Humans, Lactic Acid, Monocarboxylic Acid Transporters
Abstract

<p>Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the "Warburg effect". To accommodate the high glucose demands and to avoid lactate accumulation, the expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are elevated to maintain metabolic homeostasis. Therefore, inhibition of GLUTs and/or MCTs provides potential therapeutic strategies for cancer treatment. Here, we summarize recent advances in the structural characterization of GLUTs and MCTs, providing a comprehensive understanding of their transport and inhibition mechanisms to facilitate further development of anticancer therapies.</p>

DOI10.1002/iub.2668
Alternate JournalIUBMB Life
PubMed ID36082803
Grant ListZ201100006820039 / / Beijing Nova Program /
2020YFA0509301 / / the National Key R&D Program of China /
/ / Tsinghua-Peking Center for Life Sciences and Tsinghua University /