Title | Structural aspects of the glucose and monocarboxylate transporters involved in the Warburg effect. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Jiang, X, Yan, N, Deng, D, Yan, C |
Journal | IUBMB Life |
Volume | 74 |
Issue | 12 |
Pagination | 1180-1199 |
Date Published | 2022 Dec |
ISSN | 1521-6551 |
Keywords | Fermentation, Glucose, Humans, Lactic Acid, Monocarboxylic Acid Transporters |
Abstract | <p>Cancer cells shift their glucose catabolism from aerobic respiration to lactic fermentation even in the presence of oxygen, and this is known as the "Warburg effect". To accommodate the high glucose demands and to avoid lactate accumulation, the expression levels of human glucose transporters (GLUTs) and human monocarboxylate transporters (MCTs) are elevated to maintain metabolic homeostasis. Therefore, inhibition of GLUTs and/or MCTs provides potential therapeutic strategies for cancer treatment. Here, we summarize recent advances in the structural characterization of GLUTs and MCTs, providing a comprehensive understanding of their transport and inhibition mechanisms to facilitate further development of anticancer therapies.</p> |
DOI | 10.1002/iub.2668 |
Alternate Journal | IUBMB Life |
PubMed ID | 36082803 |
Grant List | Z201100006820039 / / Beijing Nova Program / 2020YFA0509301 / / the National Key R&D Program of China / / / Tsinghua-Peking Center for Life Sciences and Tsinghua University / |