Structural and functional diversity calls for a new classification of ABC transporters.

TitleStructural and functional diversity calls for a new classification of ABC transporters.
Publication TypeJournal Article
Year of Publication2020
AuthorsThomas, C, Aller, SG, Beis, K, Carpenter, EP, Chang, G, Chen, L, Dassa, E, Dean, M, Van Hoa, FDuong, Ekiert, D, Ford, R, Gaudet, R, Gong, X, I Holland, B, Huang, Y, Kahne, DK, Kato, H, Koronakis, V, Koth, CM, Lee, Y, Lewinson, O, Lill, R, Martinoia, E, Murakami, S, Pinkett, HW, Poolman, B, Rosenbaum, D, Sarkadi, B, Schmitt, L, Schneider, E, Shi, Y, Shyng, S-L, Slotboom, DJ, Tajkhorshid, E, D Tieleman, P, Ueda, K, Váradi, A, Wen, P-C, Yan, N, Zhang, P, Zheng, H, Zimmer, J, Tampé, R
JournalFEBS Lett
Volume594
Issue23
Pagination3767-3775
Date Published2020 12
ISSN1873-3468
KeywordsATP-Binding Cassette Transporters, Protein Domains, Protein Folding
Abstract

<p>Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.</p>

DOI10.1002/1873-3468.13935
Alternate JournalFEBS Lett
PubMed ID32978974
PubMed Central IDPMC8386196
Grant ListR01 GM140584 / GM / NIGMS NIH HHS / United States
MR/N000994/1 / MRC_ / Medical Research Council / United Kingdom
R01 GM126626 / GM / NIGMS NIH HHS / United States
101828/Z/13/Z / WT_ / Wellcome Trust / United Kingdom
MR/N020103/1 / MRC_ / Medical Research Council / United Kingdom
/ WT_ / Wellcome Trust / United Kingdom