Structural advances for the major facilitator superfamily (MFS) transporters.

TitleStructural advances for the major facilitator superfamily (MFS) transporters.
Publication TypeJournal Article
Year of Publication2013
AuthorsYan, N
JournalTrends Biochem Sci
Volume38
Issue3
Pagination151-9
Date Published2013 Mar
ISSN0968-0004
KeywordsAnimals, Humans, Membrane Transport Proteins, Protein Conformation
Abstract

The major facilitator superfamily (MFS) is one of the largest groups of secondary active transporters conserved from bacteria to humans. MFS proteins selectively transport a wide spectrum of substrates across biomembranes and play a pivotal role in multiple physiological processes. Despite intense investigation, only seven MFS proteins from six subfamilies have been structurally elucidated. These structures were captured in distinct states during a transport cycle involving alternating access to binding sites from either side of the membrane. This review discusses recent progress in MFS structure analysis and focuses on the molecular basis for substrate binding, co-transport coupling, and alternating access.

DOI10.1016/j.tibs.2013.01.003
Alternate JournalTrends Biochem. Sci.
PubMed ID23403214
Grant List / / Howard Hughes Medical Institute / United States