Spherical Caps in Cell Polarization.

TitleSpherical Caps in Cell Polarization.
Publication TypeJournal Article
Year of Publication2018
AuthorsDiegmiller, R, Montanelli, H, Muratov, CB, Shvartsman, SY
JournalBiophys J
Volume115
Issue1
Pagination26-30
Date Published2018 07 03
ISSN1542-0086
KeywordsCell Membrane, Cell Polarity, Cell Shape, Diffusion, Intracellular Space, Models, Biological
Abstract

<p>Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.</p>

DOI10.1016/j.bpj.2018.05.033
Alternate JournalBiophys. J.
PubMed ID29933887
PubMed Central IDPMC6035301
Grant ListR01 GM107103 / GM / NIGMS NIH HHS / United States