Spherical Caps in Cell Polarization.

Publication Year
2018

Type

Journal Article
Abstract

Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.

Journal
Biophys J
Volume
115
Issue
1
Pages
26-30
Date Published
2018 Jul 03
ISSN Number
1542-0086
Alternate Journal
Biophys J
PMCID
PMC6035301
PMID
29933887