Title | Spherical Caps in Cell Polarization. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Diegmiller, R, Montanelli, H, Muratov, CB, Shvartsman, SY |
Journal | Biophys J |
Volume | 115 |
Issue | 1 |
Pagination | 26-30 |
Date Published | 2018 07 03 |
ISSN | 1542-0086 |
Keywords | Cell Membrane, Cell Polarity, Cell Shape, Diffusion, Intracellular Space, Models, Biological |
Abstract | <p>Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.</p> |
DOI | 10.1016/j.bpj.2018.05.033 |
Alternate Journal | Biophys J |
PubMed ID | 29933887 |
PubMed Central ID | PMC6035301 |
Grant List | R01 GM107103 / GM / NIGMS NIH HHS / United States |