|Title||Spherical Caps in Cell Polarization.|
|Publication Type||Journal Article|
|Year of Publication||2018|
|Authors||Diegmiller, R, Montanelli, H, Muratov, CB, Shvartsman, SY|
|Date Published||2018 Jun 19|
Intracellular symmetry breaking plays a key role in wide range of biological processes, both in single cells and in multicellular organisms. An important class of symmetry-breaking mechanisms relies on the cytoplasm/membrane redistribution of proteins that can autocatalytically promote their own recruitment to the plasma membrane. We present an analytical construction and a comprehensive parametric analysis of stable localized patterns in a reaction-diffusion model of such a mechanism in a spherical cell. The constructed patterns take the form of high-concentration patches localized into spherical caps, similar to the patterns observed in the studies of symmetry breaking in single cells and early embryos.
|Alternate Journal||Biophys. J.|