Single-Particle Dynamic Light Scattering: Shapes of Individual Nanoparticles.

TitleSingle-Particle Dynamic Light Scattering: Shapes of Individual Nanoparticles.
Publication TypeJournal Article
Year of Publication2019
AuthorsGuerra, LF, Muir, TW, Yang, H
JournalNano Lett
Volume19
Issue8
Pagination5530-5536
Date Published2019 Aug 14
ISSN1530-6992
Abstract

Metallic nanoparticles (MNPs) are prevalent in modern nanotechnologies due to their unique optical properties, chemical and photostability, and ease of manipulation. In particular, many recent advances have highlighted the importance of fundamentally understanding dynamic reconfiguration in MNP morphologies and compositions. Techniques to measure the shape of a single particle are lacking, however, often requiring immobilization, extensive numerical simulations, and irreversible alterations of the particle or its environment. In this work, we introduce "single-particle dynamic light scattering" (SP-DLS) as a far-field technique capable of analyzing the shape of individual, freely diffusing MNPs. Assuming symmetric-top rotors for MNPs and passively confining them to the focal volume of a dark-field microscope for long-term observation, we directly relate polarization dynamic fluctuations in the scattered light to the relative difference between the nondegenerate axes of individual particles. Our results show remarkable agreement with transmission electron microscopy analyses of the same population and allow for unprecedented measurements of the extent of prolate or oblate asphericity of nominally spherical MNPs in solution where the current implementation affords an asphericity detection limit of ∼2.5% assuming a 10% relative error. SP-DLS should serve as a powerful, nondestructive technique for characterizing the shapes of individual MNPs and other nanostructures.

DOI10.1021/acs.nanolett.9b02066
Alternate JournalNano Lett.
PubMed ID31272153