Signal Transduction Network Principles Underlying Bacterial Collective Behaviors.

TitleSignal Transduction Network Principles Underlying Bacterial Collective Behaviors.
Publication TypeJournal Article
Year of Publication2022
AuthorsBridges, AA, Prentice, JA, Wingreen, NS, Bassler, BL
JournalAnnu Rev Microbiol
Date Published2022 May 24
ISSN1545-3251
Abstract

<p>Bacteria orchestrate collective behaviors and accomplish feats that would be unsuccessful if carried out by a lone bacterium. Processes undertaken by groups of bacteria include bioluminescence, biofilm formation, virulence factor production, and release of public goods that are shared by the community. Collective behaviors are controlled by signal transduction networks that integrate sensory information and transduce the information internally. Here, we discuss network features and mechanisms that, even in the face of dramatically changing environments, drive precise execution of bacterial group behaviors. We focus on representative quorum-sensing and second-messenger cyclic dimeric GMP (c-di-GMP) signal relays. We highlight ligand specificity versus sensitivity, how small-molecule ligands drive discrimination of kin versus nonkin, signal integration mechanisms, single-input sensory systems versus coincidence detectors, and tuning of input-output dynamics via feedback regulation. We summarize how different features of signal transduction systems allow groups of bacteria to successfully interpret and collectively react to dynamically changing environments. Expected final online publication date for the , Volume 76 is September 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.</p>

DOI10.1146/annurev-micro-042922-122020
Alternate JournalAnnu Rev Microbiol
PubMed ID35609948
Grant ListK99 AI158939 / AI / NIAID NIH HHS / United States
R21 AI146223 / AI / NIAID NIH HHS / United States