Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes.

TitleSensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes.
Publication TypeJournal Article
Year of Publication2020
AuthorsJové, V, Gong, Z, Hol, FJH, Zhao, Z, Sorrells, TR, Carroll, TS, Prakash, M, McBride, CS, Vosshall, LB
JournalNeuron
Volume108
Issue6
Pagination1163-1180.e12
Date Published2020/12/23
ISSN1097-4199
KeywordsAedes, Animals, Blood, Discrimination, Psychological, Feeding Behavior, Neurons, Plant Nectar, Taste, Taste Perception
Abstract

Blood-feeding mosquitoes survive by feeding on nectar for metabolic energy but require a blood meal to develop eggs. Aedes aegypti females must accurately discriminate blood and nectar because each meal promotes mutually exclusive feeding programs with distinct sensory appendages, meal sizes, digestive tract targets, and metabolic fates. We investigated the syringe-like blood-feeding appendage, the stylet, and discovered that sexually dimorphic stylet neurons taste blood. Using pan-neuronal calcium imaging, we found that blood is detected by four functionally distinct stylet neuron classes, each tuned to specific blood components associated with diverse taste qualities. Stylet neurons are insensitive to nectar-specific sugars and respond to glucose only in the presence of additional blood components. The distinction between blood and nectar is therefore encoded in specialized neurons at the very first level of sensory detection in mosquitoes. This innate ability to recognize blood is the basis of vector-borne disease transmission to millions of people worldwide.

DOI10.1016/j.neuron.2020.09.019
Alternate JournalNeuron
PubMed ID33049200
Grant List / HHMI / Howard Hughes Medical Institute / United States
UL1 TR000043 / TR / NCATS NIH HHS / United States
T32 MH095246 / MH / NIMH NIH HHS / United States
R00 DC012069 / DC / NIDCD NIH HHS / United States
DP2 AI124336 / AI / NIAID NIH HHS / United States