Self-assembly of tessellated tissue sheets by expansion and collision.

TitleSelf-assembly of tessellated tissue sheets by expansion and collision.
Publication TypeJournal Article
Year of Publication2022
AuthorsHeinrich, MA, Alert, R, Wolf, AE, Košmrlj, A, Cohen, DJ
JournalNat Commun
Volume13
Issue1
Pagination4026
Date Published2022 Jul 12
ISSN2041-1723
Abstract

<p>Tissues do not exist in isolation-they interact with other tissues within and across organs. While cell-cell interactions have been intensely investigated, less is known about tissue-tissue interactions. Here, we studied collisions between monolayer tissues with different geometries, cell densities, and cell types. First, we determine rules for tissue shape changes during binary collisions and describe complex cell migration at tri-tissue boundaries. Next, we propose that genetically identical tissues displace each other based on pressure gradients, which are directly linked to gradients in cell density. We present a physical model of tissue interactions that allows us to estimate the bulk modulus of the tissues from collision dynamics. Finally, we introduce TissEllate, a design tool for self-assembling complex tessellations from arrays of many tissues, and we use cell sheet engineering techniques to transfer these composite tissues like cellular films. Overall, our work provides insight into the mechanics of tissue collisions, harnessing them to engineer tissue composites as designable living materials.</p>

DOI10.1038/s41467-022-31459-1
Alternate JournalNat Commun
PubMed ID35821232
PubMed Central IDPMC9276766
Grant List1R35 GM133574-01 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) /