Secondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution.

TitleSecondary metabolites from the Burkholderia pseudomallei complex: structure, ecology, and evolution.
Publication TypeJournal Article
Year of Publication2020
AuthorsKlaus, JR, Coulon, PML, Koirala, P, Seyedsayamdost, MR, Déziel, E, Chandler, JR
JournalJ Ind Microbiol Biotechnol
Volume47
Issue9-10
Pagination877-887
Date Published2020 Oct
ISSN1476-5535
KeywordsBiosynthetic Pathways, Burkholderia, Burkholderia mallei, Burkholderia pseudomallei, Lactones, Multigene Family
Abstract

<p>Bacterial secondary metabolites play important roles in promoting survival, though few have been carefully studied in their natural context. Numerous gene clusters code for secondary metabolites in the genomes of members of the Bptm group, made up of three closely related species with distinctly different lifestyles: the opportunistic pathogen Burkholderia pseudomallei, the non-pathogenic saprophyte Burkholderia thailandensis, and the host-adapted pathogen Burkholderia mallei. Several biosynthetic gene clusters are conserved across two or all three species, and this provides an opportunity to understand how the corresponding secondary metabolites contribute to survival in different contexts in nature. In this review, we discuss three secondary metabolites from the Bptm group: bactobolin, malleilactone (and malleicyprol), and the 4-hydroxy-3-methyl-2-alkylquinolines, providing an overview of each of their biosynthetic pathways and insight into their potential ecological roles. Results of studies on these secondary metabolites provide a window into how secondary metabolites contribute to bacterial survival in different environments, from host infections to polymicrobial soil communities.</p>

DOI10.1007/s10295-020-02317-0
Alternate JournalJ Ind Microbiol Biotechnol
PubMed ID33052546
PubMed Central IDPMC7746414
Grant ListP20 GM113117 / GM / NIGMS NIH HHS / United States
MOP-142466 / CAPMC / CIHR / Canada
DP2 AI124786 / AI / NIAID NIH HHS / United States
R35 GM133572 / GM / NIGMS NIH HHS / United States
DP2-AI-124786 / NH / NIH HHS / United States
R35GM133572 / NH / NIH HHS / United States
P20 GM113117 / NH / NIH HHS / United States