SARS-CoV-2 outbreak dynamics in an isolated US military recruit training center with rigorous prevention measures.

TitleSARS-CoV-2 outbreak dynamics in an isolated US military recruit training center with rigorous prevention measures.
Publication TypeJournal Article
Year of Publication2022
AuthorsLizewski, RA, Sealfon, RSG, Park, SWoo, Smith, GR, Porter, CK, Gonzalez-Reiche, AS, Ge, Y, Miller, CM, Goforth, CW, Pincas, H, Termini, MS, Ramos, I, Nair, VD, Lizewski, SE, Alshammary, H, Cer, RZ, Chen, HWei, George, M-C, Arnold, CE, Glang, LA, Long, KA, Malagon, F, Marayag, JJ, Nunez, E, Rice, GK, Ana, ESanta, Schilling, MA, Smith, DR, Sugiharto, VA, Sun, P, van de Guchte, A, Khan, Z, Dutta, J, Vangeti, S, Voegtly, LJ, Weir, DL, C Metcalf, JE, Troyanskaya, OG, Bishop-Lilly, KA, Grenfell, BT, van Bakel, H, Letizia, AG, Sealfon, SC
JournalEpidemiology
Date Published2022/08/05
ISSN1531-5487
Abstract

BACKGROUND: Marine recruits training at Parris Island experienced an unexpectedly high rate of SARS-CoV-2 infection, despite preventive measures including a supervised, 2-week, pre-entry quarantine. We characterize SARS-CoV-2 transmission in this cohort.

METHODS: Between May and November 2020, we monitored 2469 unvaccinated, mostly male, Marine recruits prospectively during basic training. If participants tested negative for SARS-CoV-2 by quantitative polymerase chain reaction (qPCR) at the end of quarantine, they were transferred to the training site in segregated companies and underwent biweekly testing for 6 weeks. We assessed the effects of COVID-19 prevention measures on other respiratory infections with passive surveillance data, performed phylogenetic analysis, and modeled transmission dynamics and testing regimens.

RESULTS: Preventive measures were associated with drastically lower rates of other respiratory illnesses. However, among the trainees, 1107 (44.8%) tested SARS-CoV-2-positive, with either mild or no symptoms. Phylogenetic analysis of viral genomes from 580 participants revealed that all cases but one were linked to five independent introductions, each characterized by accumulation of mutations across and within companies, and similar viral isolates in individuals from the same company. Variation in company transmission rates (mean reproduction number R0, 5.5 [95% CI 5.0-6.1]) could be accounted for by multiple initial cases within a company and superspreader events. Simulations indicate that frequent rapid-report testing with case isolation may minimize outbreaks.

CONCLUSIONS: Transmission of wild-type SARS-CoV-2 among Marine recruits was approximately twice that seen in the community. Insights from SARS-CoV-2 outbreak dynamics and mutations spread in a remote, congregate setting may inform effective mitigation strategies.

DOI10.1097/EDE.0000000000001523
Alternate JournalEpidemiology
PubMed ID35944149