The round trip model for severe herpes zoster caused by live attenuated varicella vaccine virus.

Author
Charles Grose, Lynn Enquist
Publication Year
2020

Type

Journal Article
Abstract

Varicella vaccine is a live attenuated varicella‐zoster virus. Varicella vaccine can enter latency and later reactivate as herpes zoster. Pseudorabies virus is another herpesvirus closely related to varicella‐zoster virus. The round trip model for pseudorabies virus explains pathogenesis of herpes zoster from vaccine virus.

Keywords
Animals, Sensory Receptor Cells, Humans, Models, Biological, Axons, Virus Replication, Child, Child, Preschool, Herpesvirus 3, Human, Virus Activation, Skin, Virus Latency, Infant, Vaccines, Attenuated, Ganglia, Spinal, Chickenpox Vaccine, Herpes Zoster
Journal
J Med Virol
Volume
92
Issue
8
Pages
938-940
Date Published
2020 Aug
ISSN Number
1096-9071
DOI
10.1002/jmv.25664
Alternate Journal
J Med Virol
PMCID
PMC7354881
PMID
31943220