The round trip model for severe herpes zoster caused by live attenuated varicella vaccine virus.

TitleThe round trip model for severe herpes zoster caused by live attenuated varicella vaccine virus.
Publication TypeJournal Article
Year of Publication2020
AuthorsGrose, C, Enquist, LW
JournalJ Med Virol
Volume92
Issue8
Pagination938-940
Date Published2020 Aug
ISSN1096-9071
KeywordsAnimals, Axons, Chickenpox Vaccine, Child, Child, Preschool, Ganglia, Spinal, Herpes Zoster, Herpesvirus 3, Human, Humans, Infant, Models, Biological, Sensory Receptor Cells, Skin, Vaccines, Attenuated, Virus Activation, Virus Latency, Virus Replication
Abstract

<p>Varicella vaccine is a live attenuated varicella‐zoster virus. Varicella vaccine can enter latency and later reactivate as herpes zoster. Pseudorabies virus is another herpesvirus closely related to varicella‐zoster virus. The round trip model for pseudorabies virus explains pathogenesis of herpes zoster from vaccine virus.</p>

DOI10.1002/jmv.25664
Alternate JournalJ Med Virol
PubMed ID31943220
PubMed Central IDPMC7354881
Grant ListR01 HL126667 / HL / NHLBI NIH HHS / United States
R37 NS033506 / NS / NINDS NIH HHS / United States
HL126667 / NH / NIH HHS / United States