Roseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.

TitleRoseochelin B, an Algaecidal Natural Product Synthesized by the Roseobacter Phaeobacter inhibens in Response to Algal Sinapic Acid.
Publication TypeJournal Article
Year of Publication2017
AuthorsWang, R, Seyedsayamdost, MR
JournalOrg Lett
Volume19
Issue19
Pagination5138-5141
Date Published2017 Oct 06
ISSN1523-7052
Abstract

The secondary metabolome of the representative Roseobacter, Phaeobacter inhibens, was examined in response to algal sinapic acid. In addition to roseobacticides, sinapic acid induced the production of two new natural products, roseochelin A and B, which were characterized by NMR and X-ray crystallography. Functional assays showed that roseochelin B binds iron and is algaecidal against the algal host Emiliania huxleyi. It appears to be produced by a rarely observed combination of nonenzymatic and enzymatic transformations.

DOI10.1021/acs.orglett.7b02424
Alternate JournalOrg. Lett.
PubMed ID28920692