Role Reversal: A Pro-metastatic Function of E-Cadherin.

TitleRole Reversal: A Pro-metastatic Function of E-Cadherin.
Publication TypeJournal Article
Year of Publication2019
AuthorsShen, M, Kang, Y
JournalDev Cell
Volume51
Issue4
Pagination417-419
Date Published2019 11 18
ISSN1878-1551
KeywordsBreast Neoplasms, Cadherins, Cell Line, Tumor, Epithelial-Mesenchymal Transition, Humans
Abstract

<p>Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.</p>

DOI10.1016/j.devcel.2019.10.028
Alternate JournalDev. Cell
PubMed ID31743661