Title | Role Reversal: A Pro-metastatic Function of E-Cadherin. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Shen, M, Kang, Y |
Journal | Dev Cell |
Volume | 51 |
Issue | 4 |
Pagination | 417-419 |
Date Published | 2019 Nov 18 |
ISSN | 1878-1551 |
Keywords | Breast Neoplasms, Cadherins, Cell Line, Tumor, Epithelial-Mesenchymal Transition, Humans |
Abstract | <p>Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.</p> |
DOI | 10.1016/j.devcel.2019.10.028 |
Alternate Journal | Dev Cell |
PubMed ID | 31743661 |