Role of the Membrane for Mechanosensing by Tethered Channels.

TitleRole of the Membrane for Mechanosensing by Tethered Channels.
Publication TypeJournal Article
Year of Publication2016
AuthorsSabass, B, Stone, HA
JournalPhys Rev Lett
Volume116
Issue25
Pagination258101
Date Published2016 Jun 24
ISSN1079-7114
Abstract

Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.

DOI10.1103/PhysRevLett.116.258101
Alternate JournalPhys. Rev. Lett.
PubMed ID27391754