Role of the Membrane for Mechanosensing by Tethered Channels.

Publication Year
2016

Type

Journal Article
Abstract

Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.

Journal
Phys Rev Lett
Volume
116
Issue
25
Pages
258101
Date Published
2016 Jun 24
ISSN Number
1079-7114
Alternate Journal
Phys Rev Lett
PMID
27391754