|Title||Role of the Membrane for Mechanosensing by Tethered Channels.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Sabass, B, Stone, HA|
|Journal||Phys Rev Lett|
|Date Published||2016 Jun 24|
Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels.
|Alternate Journal||Phys. Rev. Lett.|