Title | Role of the Membrane for Mechanosensing by Tethered Channels. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Sabass, B, Stone, HA |
Journal | Phys Rev Lett |
Volume | 116 |
Issue | 25 |
Pagination | 258101 |
Date Published | 2016 Jun 24 |
ISSN | 1079-7114 |
Abstract | Biologically important membrane channels are gated by force at attached tethers. Here, we generically characterize the nontrivial interplay of force, membrane tension, and channel deformations that can affect gating. A central finding is that minute conical channel deformation under force leads to significant energy release during opening. We also calculate channel-channel interactions and show that they can amplify the force sensitivity of tethered channels. |
DOI | 10.1103/PhysRevLett.116.258101 |
Alternate Journal | Phys. Rev. Lett. |
PubMed ID | 27391754 |