Roadmap on biology in time varying environments.

TitleRoadmap on biology in time varying environments.
Publication TypeJournal Article
Year of Publication2021
AuthorsMurugan, A, Husain, K, Rust, MJ, Hepler, C, Bass, J, Pietsch, JMJ, Swain, PS, Jena, SG, Toettcher, JE, Chakraborty, AK, Sprenger, KG, Mora, T, Walczak, AM, Rivoire, O, Wang, S, Wood, KB, Skanata, A, Kussell, E, Ranganathan, R, Shih, H-Y, Goldenfeld, N
JournalPhys Biol
Date Published2021 05 17
KeywordsBiological Evolution, Environment, Physiological Phenomena, Time Factors

<p>Biological organisms experience constantly changing environments, from sudden changes in physiology brought about by feeding, to the regular rising and setting of the Sun, to ecological changes over evolutionary timescales. Living organisms have evolved to thrive in this changing world but the general principles by which organisms shape and are shaped by time varying environments remain elusive. Our understanding is particularly poor in the intermediate regime with no separation of timescales, where the environment changes on the same timescale as the physiological or evolutionary response. Experiments to systematically characterize the response to dynamic environments are challenging since such environments are inherently high dimensional. This roadmap deals with the unique role played by time varying environments in biological phenomena across scales, from physiology to evolution, seeking to emphasize the commonalities and the challenges faced in this emerging area of research.</p>

Alternate JournalPhys Biol
PubMed ID33477124
PubMed Central IDPMC8652373
Grant ListR01 GM120231 / GM / NIGMS NIH HHS / United States
R01 GM135382 / GM / NIGMS NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States