Restoring metabolism of myeloid cells reverses cognitive decline in ageing.

TitleRestoring metabolism of myeloid cells reverses cognitive decline in ageing.
Publication TypeJournal Article
Year of Publication2021
AuthorsMinhas, PS, Latif-Hernandez, A, McReynolds, MR, Durairaj, AS, Wang, Q, Rubin, A, Joshi, AU, He, JQ, Gauba, E, Liu, L, Wang, C, Linde, M, Sugiura, Y, Moon, PK, Majeti, R, Suematsu, M, Mochly-Rosen, D, Weissman, IL, Longo, FM, Rabinowitz, JD, Andreasson, KI
JournalNature
Volume590
Issue7844
Pagination122-128
Date Published2021 02
ISSN1476-4687
KeywordsAdult, Aged, Aging, Animals, Cell Respiration, Cells, Cultured, Cognitive Dysfunction, Dinoprostone, Energy Metabolism, Glucose, Glycogen, Humans, Inflammation, Macrophages, Memory Disorders, Mice, Microglia, Mitochondria, Myeloid Cells, Receptors, Prostaglandin E, EP2 Subtype, Signal Transduction, Spatial Memory
Abstract

<p>Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease. Systemically, circulating pro-inflammatory factors can promote cognitive decline, and in the brain, microglia lose the ability to clear misfolded proteins that are associated with neurodegeneration. However, the underlying mechanisms that initiate and sustain maladaptive inflammation with ageing are not well defined. Here we show that in ageing mice myeloid cell bioenergetics are suppressed in response to increased signalling by the lipid messenger prostaglandin E (PGE), a major modulator of inflammation. In ageing macrophages and microglia, PGE signalling through its EP2 receptor promotes the sequestration of glucose into glycogen, reducing glucose flux and mitochondrial respiration. This energy-deficient state, which drives maladaptive pro-inflammatory responses, is further augmented by a dependence of aged myeloid cells on glucose as a principal fuel source. In aged mice, inhibition of myeloid EP2 signalling rejuvenates cellular bioenergetics, systemic and brain inflammatory states, hippocampal synaptic plasticity and spatial memory. Moreover, blockade of peripheral myeloid EP2 signalling is sufficient to restore cognition in aged mice. Our study suggests that cognitive ageing is not a static or irrevocable condition but can be reversed by reprogramming myeloid glucose metabolism to restore youthful immune functions.</p>

DOI10.1038/s41586-020-03160-0
Alternate JournalNature
PubMed ID33473210
PubMed Central IDPMC8274816
Grant ListR35 CA220434 / CA / NCI NIH HHS / United States
/ WT_ / Wellcome Trust / United Kingdom
DP1 DK113643 / DK / NIDDK NIH HHS / United States
R21 NS087639 / NS / NINDS NIH HHS / United States
P30 AG066515 / AG / NIA NIH HHS / United States
RF1 AG058047 / AG / NIA NIH HHS / United States
F30 CA228215 / CA / NCI NIH HHS / United States
1S10RR02678001 / NH / NIH HHS / United States
R01 AG048232 / AG / NIA NIH HHS / United States
P50 AG047366 / AG / NIA NIH HHS / United States
/ AHA / American Heart Association-American Stroke Association / United States