Representative subsampling of sedimenting blood.

Publication Year
2019

Type

Journal Article
Abstract

It is often necessary to extract a small amount of a suspension, such as blood, from a larger sample of the same material for the purposes of diagnostics, testing or imaging. A practical challenge is that the cells in blood sediment noticeably on the time scale of a few minutes, making a representative subsampling of the original sample challenging. Guided by experimental data, we develop a Kynch sedimentation model to discuss design considerations that ensure a representative subsampling of blood, from a container of constant cross-sectional area, for the entire range of physiologically relevant hematocrit over a specified time of interest. Additionally, we show that this design may be modified to exploit the sedimentation and perform subsampling to achieve either higher or lower hematocrit relative to that of the original sample. Thus, our method provides a simple tool to either concentrate or dilute small quantities of blood or other sedimenting suspensions.

Journal
Proc Math Phys Eng Sci
Volume
475
Issue
2227
Pages
20190223
Date Published
2019 Jul
ISSN Number
1364-5021
Alternate Journal
Proc Math Phys Eng Sci
PMCID
PMC6694302
PMID
31423102