Representative subsampling of sedimenting blood. Author Bhargav Rallabandi, Janine Nunes, Antonio Perazzo, Sergey Gershtein, Howard Stone Publication Year 2019 Type Journal Article Abstract It is often necessary to extract a small amount of a suspension, such as blood, from a larger sample of the same material for the purposes of diagnostics, testing or imaging. A practical challenge is that the cells in blood sediment noticeably on the time scale of a few minutes, making a representative subsampling of the original sample challenging. Guided by experimental data, we develop a Kynch sedimentation model to discuss design considerations that ensure a representative subsampling of blood, from a container of constant cross-sectional area, for the entire range of physiologically relevant hematocrit over a specified time of interest. Additionally, we show that this design may be modified to exploit the sedimentation and perform subsampling to achieve either higher or lower hematocrit relative to that of the original sample. Thus, our method provides a simple tool to either concentrate or dilute small quantities of blood or other sedimenting suspensions. Journal Proc Math Phys Eng Sci Volume 475 Issue 2227 Pages 20190223 Date Published 2019 Jul ISSN Number 1364-5021 DOI 10.1098/rspa.2019.0223 Alternate Journal Proc Math Phys Eng Sci PMCID PMC6694302 PMID 31423102 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML