Rationale and design of the Kidney Precision Medicine Project.

TitleRationale and design of the Kidney Precision Medicine Project.
Publication TypeJournal Article
Year of Publication2021
Authorsde Boer, IH, Alpers, CE, Azeloglu, EU, Balis, UGJ, Barasch, JM, Barisoni, L, Blank, KN, Bomback, AS, Brown, K, Dagher, PC, Dighe, AL, Eadon, MT, El-Achkar, TM, Gaut, JP, Hacohen, N, He, Y, Hodgin, JB, Jain, S, Kellum, JA, Kiryluk, K, Knight, R, Laszik, ZG, Lienczewski, C, Mariani, LH, McClelland, RL, Menez, S, Moledina, DG, Mooney, SD, O'Toole, JF, Palevsky, PM, Parikh, CR, Poggio, ED, Rosas, SE, Rosengart, MR, Sarwal, MM, Schaub, JA, Sedor, JR, Sharma, K, Steck, B, Toto, RD, Troyanskaya, OG, Tuttle, KR, Vazquez, MA, Waikar, SS, Williams, K, Wilson, FPerry, Zhang, K, Iyengar, R, Kretzler, M, Himmelfarb, J
Corporate Authors
JournalKidney Int
Volume99
Issue3
Pagination498-510
Date Published2021 03
ISSN1523-1755
Abstract

Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous, and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate a precision-medicine approach to prevention, diagnosis, and treatment. The Kidney Precision Medicine Project aims to ethically and safely obtain kidney biopsies from participants with CKD or AKI, create a reference kidney atlas, and characterize disease subgroups to stratify patients based on molecular features of disease, clinical characteristics, and associated outcomes. An additional aim is to identify critical cells, pathways, and targets for novel therapies and preventive strategies. This project is a multicenter prospective cohort study of adults with CKD or AKI who undergo a protocol kidney biopsy for research purposes. This investigation focuses on kidney diseases that are most prevalent and therefore substantially burden the public health, including CKD attributed to diabetes or hypertension and AKI attributed to ischemic and toxic injuries. Reference kidney tissues (for example, living-donor kidney biopsies) will also be evaluated. Traditional and digital pathology will be combined with transcriptomic, proteomic, and metabolomic analysis of the kidney tissue as well as deep clinical phenotyping for supervised and unsupervised subgroup analysis and systems biology analysis. Participants will be followed prospectively for 10 years to ascertain clinical outcomes. Cell types, locations, and functions will be characterized in health and disease in an open, searchable, online kidney tissue atlas. All data from the Kidney Precision Medicine Project will be made readily available for broad use by scientists, clinicians, and patients.

DOI10.1016/j.kint.2020.08.039
Alternate JournalKidney Int
PubMed ID33637194
Grant ListUH3 DK114923 / DK / NIDDK NIH HHS / United States
UH3 DK114908 / DK / NIDDK NIH HHS / United States
UH3 DK114920 / DK / NIDDK NIH HHS / United States
UH3 DK114870 / DK / NIDDK NIH HHS / United States
UH3 DK114915 / DK / NIDDK NIH HHS / United States
UH3 DK114926 / DK / NIDDK NIH HHS / United States
UH3 DK114861 / DK / NIDDK NIH HHS / United States
UH3 DK114933 / DK / NIDDK NIH HHS / United States
UH3 DK114937 / DK / NIDDK NIH HHS / United States
UH3 DK114907 / DK / NIDDK NIH HHS / United States
UH3 DK114866 / DK / NIDDK NIH HHS / United States
P30 DK036836 / DK / NIDDK NIH HHS / United States
U2C DK114886 / DK / NIDDK NIH HHS / United States