Quorum sensing signal-response systems in Gram-negative bacteria.

TitleQuorum sensing signal-response systems in Gram-negative bacteria.
Publication TypeJournal Article
Year of Publication2016
AuthorsPapenfort, K, Bassler, BL
JournalNat Rev Microbiol
Date Published2016 Aug 11
KeywordsAnti-Bacterial Agents, Bacterial Proteins, Gram-Negative Bacteria, Pheromones, Quorum Sensing, Signal Transduction

<p>Bacteria use quorum sensing to orchestrate gene expression programmes that underlie collective behaviours. Quorum sensing relies on the production, release, detection and group-level response to extracellular signalling molecules, which are called autoinducers. Recent work has discovered new autoinducers in Gram-negative bacteria, shown how these molecules are recognized by cognate receptors, revealed new regulatory components that are embedded in canonical signalling circuits and identified novel regulatory network designs. In this Review we examine how, together, these features of quorum sensing signal-response systems combine to control collective behaviours in Gram-negative bacteria and we discuss the implications for host-microbial associations and antibacterial therapy.</p>

Alternate JournalNat Rev Microbiol
PubMed ID27510864
PubMed Central IDPMC5056591
Grant List / HHMI_ / Howard Hughes Medical Institute / United States
R01 GM065859 / GM / NIGMS NIH HHS / United States
R37 GM065859 / GM / NIGMS NIH HHS / United States