Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.

TitleQuorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264.
Publication TypeJournal Article
Year of Publication2010
AuthorsSeyedsayamdost, MR, Chandler, JR, Blodgett, JAV, Lima, PS, Duerkop, BA, Oinuma, K-I, E Greenberg, P, Clardy, J
JournalOrg Lett
Volume12
Issue4
Pagination716-9
Date Published2010 Feb 19
ISSN1523-7052
KeywordsAcyl-Butyrolactones, Anti-Bacterial Agents, Benzopyrans, Burkholderia, Gene Expression Regulation, Bacterial, Humans, Quorum Sensing
Abstract

<p>Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.</p>

DOI10.1021/ol902751x
Alternate JournalOrg. Lett.
PubMed ID20095633
PubMed Central IDPMC2821070
Grant ListU54 AI057141 / AI / NIAID NIH HHS / United States
R01 GM086258 / GM / NIGMS NIH HHS / United States
U54AI057141 / AI / NIAID NIH HHS / United States
GM086258 / GM / NIGMS NIH HHS / United States
F32 AI073027-01A2 / AI / NIAID NIH HHS / United States
F32 AI073027 / AI / NIAID NIH HHS / United States