Title | Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Seyedsayamdost, MR, Chandler, JR, Blodgett, JAV, Lima, PS, Duerkop, BA, Oinuma, K-I, E Greenberg, P, Clardy, J |
Journal | Org Lett |
Volume | 12 |
Issue | 4 |
Pagination | 716-9 |
Date Published | 2010 Feb 19 |
ISSN | 1523-7052 |
Keywords | Acyl-Butyrolactones, Anti-Bacterial Agents, Benzopyrans, Burkholderia, Gene Expression Regulation, Bacterial, Humans, Quorum Sensing |
Abstract | <p>Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.</p> |
DOI | 10.1021/ol902751x |
Alternate Journal | Org Lett |
PubMed ID | 20095633 |
PubMed Central ID | PMC2821070 |
Grant List | U54 AI057141 / AI / NIAID NIH HHS / United States R01 GM086258 / GM / NIGMS NIH HHS / United States U54AI057141 / AI / NIAID NIH HHS / United States GM086258 / GM / NIGMS NIH HHS / United States F32 AI073027-01A2 / AI / NIAID NIH HHS / United States F32 AI073027 / AI / NIAID NIH HHS / United States |