| Title | Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Seyedsayamdost, MR, Chandler, JR, Blodgett, JAV, Lima, PS, Duerkop, BA, Oinuma, K-I, E Greenberg, P, Clardy, J |
| Journal | Org Lett |
| Volume | 12 |
| Issue | 4 |
| Pagination | 716-9 |
| Date Published | 2010 Feb 19 |
| ISSN | 1523-7052 |
| Keywords | Acyl-Butyrolactones, Anti-Bacterial Agents, Benzopyrans, Burkholderia, Gene Expression Regulation, Bacterial, Humans, Quorum Sensing |
| Abstract | <p>Bacterial acyl-homoserine lactones upregulated an uncharacterized gene cluster (bta) in Burkholderia thailandensis E264 to produce an uncharacterized polar antibiotic. The antibiotic is identified as a mixture of four bactobolins. Annotation of the bta cluster allows us to propose a biosynthetic scheme for bactobolin and reveals unusual enzymatic reactions for further study.</p> |
| DOI | 10.1021/ol902751x |
| Alternate Journal | Org Lett |
| PubMed ID | 20095633 |
| PubMed Central ID | PMC2821070 |
| Grant List | U54 AI057141 / AI / NIAID NIH HHS / United States R01 GM086258 / GM / NIGMS NIH HHS / United States U54AI057141 / AI / NIAID NIH HHS / United States GM086258 / GM / NIGMS NIH HHS / United States F32 AI073027-01A2 / AI / NIAID NIH HHS / United States F32 AI073027 / AI / NIAID NIH HHS / United States |
