Title | Quantifying Current Events Identifies a Novel Endurance Regulator. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Henry, TC, Brynildsen, MP |
Journal | Trends Microbiol |
Volume | 24 |
Issue | 5 |
Pagination | 324-326 |
Date Published | 2016 May |
ISSN | 1878-4380 |
Keywords | Alanine, Amino Acids, Bacteria, Bacterial Proteins, Biofilms, Microbiological Techniques, Proteome, Pseudomonas aeruginosa |
Abstract | <p>In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism.</p> |
DOI | 10.1016/j.tim.2016.02.014 |
Alternate Journal | Trends Microbiol |
PubMed ID | 26954590 |
PubMed Central ID | PMC4841710 |
Grant List | F30 AI114163 / AI / NIAID NIH HHS / United States F30AI114163 / AI / NIAID NIH HHS / United States |