Quantifying Current Events Identifies a Novel Endurance Regulator.

TitleQuantifying Current Events Identifies a Novel Endurance Regulator.
Publication TypeJournal Article
Year of Publication2016
AuthorsHenry, TC, Brynildsen, MP
JournalTrends Microbiol
Volume24
Issue5
Pagination324-326
Date Published2016 May
ISSN1878-4380
KeywordsAlanine, Amino Acids, Bacteria, Bacterial Proteins, Biofilms, Microbiological Techniques, Proteome, Pseudomonas aeruginosa
Abstract

<p>In nongrowing microbes, proteome turnover is reduced and identification of newly synthesized, low-abundance proteins is challenging. Babin and colleagues recently utilized bio-orthogonal noncanonical amino acid tagging (BONCAT) to identify actively synthesized proteins in nongrowing Pseudomonas aeruginosa, discovering a regulator whose influences range from biofilm formation to secondary metabolism. </p>

DOI10.1016/j.tim.2016.02.014
Alternate JournalTrends Microbiol.
PubMed ID26954590
PubMed Central IDPMC4841710
Grant ListF30 AI114163 / AI / NIAID NIH HHS / United States
F30AI114163 / AI / NIAID NIH HHS / United States