pSTAT3 Reactive Astrocytes Promote Brain Metastasis.

TitlepSTAT3 Reactive Astrocytes Promote Brain Metastasis.
Publication TypeJournal Article
Year of Publication2018
AuthorsShen, M, Kang, Y
JournalTrends Mol Med
Volume24
Issue9
Pagination733-735
Date Published2018 09
ISSN1471-499X
KeywordsAstrocytes, Brain, Brain Neoplasms, Humans, STAT3 Transcription Factor, Stromal Cells, Tumor Microenvironment
Abstract

<p>The tumor microenvironment contains heterogeneous populations of stromal cells with important roles in cancer progression and metastasis. In a recent study published in Nature Medicine, pSTAT3 reactive astrocytes were found to promote brain metastasis by altering the tumor microenvironment, and represent a promising target for the treatment of brain metastasis.</p>

DOI10.1016/j.molmed.2018.07.002
Alternate JournalTrends Mol Med
PubMed ID30029985