Proteomics of nucleocytoplasmic partitioning.

Publication Year
2019

Type

Journal Article
Abstract

The partitioning of the proteome between nucleus and cytoplasm affects nearly every aspect of eukaryotic biology. Despite this central role, we still have a poor understanding of which proteins localize in the nucleus and how this varies in different cell types and conditions. Recent advances in quantitative proteomics and high-throughput imaging are starting to close this knowledge gap. Studies on protein interaction are beginning to reveal the spectrum of cargos of nuclear import and export receptors. We anticipate that it will soon be possible to predict each protein's nucleocytoplasmic localization based on its importin/exportin interactions and its estimated diffusion rate through the nuclear pore. This insight is likely to provide us with a fundamental understanding of how cells use nucleocytoplasmic partitioning to encode and relay information.

Journal
Curr Opin Chem Biol
Volume
48
Pages
55-63
Date Published
2019 Feb
ISSN Number
1879-0402
Alternate Journal
Curr Opin Chem Biol
PMCID
PMC6382543
PMID
30472625