Promoting validation and cross-phylogenetic integration in model organism research.

TitlePromoting validation and cross-phylogenetic integration in model organism research.
Publication TypeJournal Article
Year of Publication2022
AuthorsCheng, KC, Burdine, RD, Dickinson, ME, Ekker, SC, Lin, AY, Lloyd, KCKent, Lutz, CM, MacRae, CA, Morrison, JH, O'Connor, DH, Postlethwait, JH, Rogers, CD, Sanchez, S, Simpson, JH, Talbot, WS, Wallace, DC, Weimer, JM, Bellen, HJ
JournalDis Model Mech
Volume15
Issue9
Date Published2022 Sep 01
ISSN1754-8411
KeywordsAnimals, Biological Evolution, Humans, Phylogeny, Reproducibility of Results
Abstract

<p>Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organism-based chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National Institutes of Health across more than 10 weeks yielded important suggestions for improving the rigor, validation, reproducibility and translatability of MO research. The effort clarified challenges and opportunities for developing and integrating tools and resources. Maintenance of critical existing infrastructure and the implementation of suggested improvements will play important roles in maintaining productivity and facilitating the validation of animal models of human biology and disease.</p>

DOI10.1242/dmm.049600
Alternate JournalDis Model Mech
PubMed ID36125045
PubMed Central IDPMC9531892
Grant ListU24 DK092993 / DK / NIDDK NIH HHS / United States
R24 OD017870 / OD / NIH HHS / United States
P51 OD011107 / OD / NIH HHS / United States
R35 NS111584 / NS / NINDS NIH HHS / United States
UM1 HG006348 / HG / NHGRI NIH HHS / United States
U42 OD012210 / OD / NIH HHS / United States
R21 NS114618 / NS / NINDS NIH HHS / United States
U42 OD026645 / OD / NIH HHS / United States
R24 OD018559 / OD / NIH HHS / United States
U54 NS079201 / NS / NINDS NIH HHS / United States
U54 OD030165 / OD / NIH HHS / United States
R01 AR071486 / AR / NIAMS NIH HHS / United States
R24 OD031447 / OD / NIH HHS / United States
Z01 OD022005 / ImNIH / Intramural NIH HHS / United States
UM1 OD023221 / OD / NIH HHS / United States
R01 OD011116 / OD / NIH HHS / United States
R01 NS110866 / NS / NINDS NIH HHS / United States
R03 OD030597 / OD / NIH HHS / United States
R01 GM063904 / GM / NIGMS NIH HHS / United States
U54 NS093793 / NS / NINDS NIH HHS / United States
R24 OD022005 / OD / NIH HHS / United States
R24 OD026591 / OD / NIH HHS / United States
U2C DK092993 / DK / NIDDK NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States