The promise of optogenetics in cell biology: interrogating molecular circuits in space and time.

TitleThe promise of optogenetics in cell biology: interrogating molecular circuits in space and time.
Publication TypeJournal Article
Year of Publication2011
AuthorsToettcher, JE, Voigt, CA, Weiner, OD, Lim, WA
JournalNat Methods
Volume8
Issue1
Pagination35-8
Date Published2011 Jan
ISSN1548-7105
KeywordsCell Biology, Cytological Techniques, Gene Expression Regulation, Genetic Techniques, Light, Luminescent Proteins, Photic Stimulation, Signal Transduction, Time Factors
Abstract

<p>Optogenetic modules offer cell biologists unprecedented new ways to poke and prod cells. The combination of these precision perturbative tools with observational tools, such as fluorescent proteins, may dramatically accelerate our ability to understand the inner workings of the cell.</p>

DOI10.1038/nmeth.f.326
Alternate JournalNat Methods
PubMed ID21191370
PubMed Central IDPMC3024327
Grant ListGM081879 / GM / NIGMS NIH HHS / United States
GM55040 / GM / NIGMS NIH HHS / United States
AI067699 / AI / NIAID NIH HHS / United States
R01 GM084040 / GM / NIGMS NIH HHS / United States
P50 GM081879 / GM / NIGMS NIH HHS / United States
R01 GM055040 / GM / NIGMS NIH HHS / United States
R01 GM095765 / GM / NIGMS NIH HHS / United States
PN2 EY016546 / EY / NEI NIH HHS / United States
EY016546 / EY / NEI NIH HHS / United States
R01 AI067699 / AI / NIAID NIH HHS / United States
PN1 EY016546 / EY / NEI NIH HHS / United States
R56 AI067699 / AI / NIAID NIH HHS / United States
R01 GM062583 / GM / NIGMS NIH HHS / United States
GM62583 / GM / NIGMS NIH HHS / United States
GM084040 / GM / NIGMS NIH HHS / United States
R01 GM084040-03 / GM / NIGMS NIH HHS / United States