Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.

TitleProgress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.
Publication TypeJournal Article
Year of Publication2021
AuthorsOmenn, GS, Lane, L, Overall, CM, Paik, Y-K, Cristea, IM, Corrales, FJ, Lindskog, C, Weintraub, S, Roehrl, MHA, Liu, S, Bandeira, N, Srivastava, S, Chen, Y-J, Aebersold, R, Moritz, RL, Deutsch, EW
JournalJ Proteome Res
Volume20
Issue12
Pagination5227-5240
Date Published2021 12 03
ISSN1535-3907
KeywordsBenchmarking, Databases, Protein, Humans, Mass Spectrometry, Proteome, Proteomics
Abstract

<p>The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 predicted proteins coded in the human genome, a gain of 483 since 2020 from reports throughout the world reanalyzed by the HPP. Conversely, the number of neXtProt PE2, PE3, and PE4 missing proteins has been reduced by 478 to 1421. This represents remarkable progress on the proteome parts list. The utilization of proteomics in a broad array of biological and clinical studies likewise continues to expand with many important findings and effective integration with other omics platforms. We present highlights from the Immunopeptidomics, Glycoproteomics, Infectious Disease, Cardiovascular, Musculo-Skeletal, Liver, and Cancers B/D-HPP teams and from the Knowledgebase, Mass Spectrometry, Antibody Profiling, and Pathology resource pillars, as well as ethical considerations important to the clinical utilization of proteomics and protein biomarkers.</p>

DOI10.1021/acs.jproteome.1c00590
Alternate JournalJ Proteome Res
PubMed ID34670092
Grant ListP30 ES017885 / ES / NIEHS NIH HHS / United States
R21 CA251992 / CA / NCI NIH HHS / United States
R21 CA263262 / CA / NCI NIH HHS / United States
U24 CA210967 / CA / NCI NIH HHS / United States
R01 GM087221 / GM / NIGMS NIH HHS / United States
R24 GM127667 / GM / NIGMS NIH HHS / United States
U19 AG023122 / AG / NIA NIH HHS / United States
U01 CA253217 / CA / NCI NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
R01 GM114141 / GM / NIGMS NIH HHS / United States