Predictability and hierarchy in Drosophila behavior.

TitlePredictability and hierarchy in Drosophila behavior.
Publication TypeJournal Article
Year of Publication2016
AuthorsBerman, GJ, Bialek, W, Shaevitz, JW
JournalProc Natl Acad Sci U S A
Volume113
Issue42
Pagination11943-11948
Date Published2016 Oct 18
ISSN1091-6490
Abstract

Even the simplest of animals exhibit behavioral sequences with complex temporal dynamics. Prominent among the proposed organizing principles for these dynamics has been the idea of a hierarchy, wherein the movements an animal makes can be understood as a set of nested subclusters. Although this type of organization holds potential advantages in terms of motion control and neural circuitry, measurements demonstrating this for an animal's entire behavioral repertoire have been limited in scope and temporal complexity. Here, we use a recently developed unsupervised technique to discover and track the occurrence of all stereotyped behaviors performed by fruit flies moving in a shallow arena. Calculating the optimally predictive representation of the fly's future behaviors, we show that fly behavior exhibits multiple time scales and is organized into a hierarchical structure that is indicative of its underlying behavioral programs and its changing internal states.

DOI10.1073/pnas.1607601113
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID27702892
PubMed Central IDPMC5081631
Grant ListP50 GM071508 / GM / NIGMS NIH HHS / United States
R01 GM098090 / GM / NIGMS NIH HHS / United States