Pre-metastatic niches: organ-specific homes for metastases.

TitlePre-metastatic niches: organ-specific homes for metastases.
Publication TypeJournal Article
Year of Publication2017
AuthorsPeinado, H, Zhang, H, Matei, IR, Costa-Silva, B, Hoshino, A, Rodrigues, G, Psaila, B, Kaplan, RN, Bromberg, JF, Kang, Y, Bissell, MJ, Cox, TR, Giaccia, AJ, Erler, JT, Hiratsuka, S, Ghajar, CM, Lyden, D
JournalNat Rev Cancer
Date Published2017 May
KeywordsAnimals, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic Cells, Circulating, Tumor Microenvironment

<p>It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.</p>

Alternate JournalNat Rev Cancer
PubMed ID28303905
Grant ListP30 CA008748 / CA / NCI NIH HHS / United States
U01 CA169538 / CA / NCI NIH HHS / United States
U54 CA193461 / CA / NCI NIH HHS / United States