Pre-metastatic niches: organ-specific homes for metastases.

TitlePre-metastatic niches: organ-specific homes for metastases.
Publication TypeJournal Article
Year of Publication2017
AuthorsPeinado, H, Zhang, H, Matei, IR, Costa-Silva, B, Hoshino, A, Rodrigues, G, Psaila, B, Kaplan, RN, Bromberg, JF, Kang, Y, Bissell, MJ, Cox, TR, Giaccia, AJ, Erler, JT, Hiratsuka, S, Ghajar, CM, Lyden, D
JournalNat Rev Cancer
Volume17
Issue5
Pagination302-317
Date Published2017 05
ISSN1474-1768
KeywordsAnimals, Humans, Neoplasm Metastasis, Neoplasms, Neoplastic Cells, Circulating, Tumor Microenvironment
Abstract

<p>It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.</p>

DOI10.1038/nrc.2017.6
Alternate JournalNat. Rev. Cancer
PubMed ID28303905
Grant ListU54 CA193461 / CA / NCI NIH HHS / United States
U01 CA169538 / CA / NCI NIH HHS / United States