Pre-metastatic niches: organ-specific homes for metastases. Author Héctor Peinado, Haiying Zhang, Irina Matei, Bruno Costa-Silva, Ayuko Hoshino, Goncalo Rodrigues, Bethan Psaila, Rosandra Kaplan, Jacqueline Bromberg, Yibin Kang, Mina Bissell, Thomas Cox, Amato Giaccia, Janine Erler, Sachie Hiratsuka, Cyrus Ghajar, David Lyden Publication Year 2017 Type Journal Article Abstract It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche. Keywords Animals, Humans, Neoplastic Cells, Circulating, Tumor Microenvironment, Neoplasms, Neoplasm Metastasis Journal Nat Rev Cancer Volume 17 Issue 5 Pages 302-317 Date Published 2017 May ISSN Number 1474-1768 DOI 10.1038/nrc.2017.6 Alternate Journal Nat Rev Cancer PMID 28303905 PubMedGoogle ScholarBibTeXEndNote X3 XML