Pre-metastatic niches: organ-specific homes for metastases.

TitlePre-metastatic niches: organ-specific homes for metastases.
Publication TypeJournal Article
Year of Publication2017
AuthorsPeinado, H, Zhang, H, Matei, IR, Costa-Silva, B, Hoshino, A, Rodrigues, G, Psaila, B, Kaplan, RN, Bromberg, JF, Kang, Y, Bissell, MJ, Cox, TR, Giaccia, AJ, Erler, JT, Hiratsuka, S, Ghajar, CM, Lyden, D
JournalNat Rev Cancer
Date Published2017 Mar 17

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Alternate JournalNat. Rev. Cancer
PubMed ID28303905