Type

Journal Article
Abstract

It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Journal
Nat Rev Cancer
Volume
17
Issue
5
Pages
302-317
Date Published
2017 May
ISSN Number
1474-1768
Alternate Journal
Nat Rev Cancer
PMID
28303905