Positional Information and Cell Fate Determination in the Early Drosophila Embryo.

TitlePositional Information and Cell Fate Determination in the Early Drosophila Embryo.
Publication TypeJournal Article
Year of Publication2016
AuthorsWieschaus, E
JournalCurr Top Dev Biol
Volume117
Pagination567-79
Date Published2016
ISSN1557-8933
KeywordsAnimals, Body Patterning, Cell Differentiation, Cell Lineage, Cell Polarity, Drosophila, Drosophila Proteins, Embryo, Nonmammalian
Abstract

During early development in Drosophila, the spatial information of maternal gradients is translated into discrete transcriptional states determining cell fate. Information transfer depends on reproducibility of the gradients themselves, as well as the ability of cells to accurately measure and utilize morphogen concentrations in biologically meaning ways. In the following essay, these issues are discussed in context of the Bicoid gradient.

DOI10.1016/bs.ctdb.2015.11.020
Alternate JournalCurr. Top. Dev. Biol.
PubMed ID26970001