Title | Planar cell polarity: global inputs establishing cellular asymmetry. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Aw, WYih, Devenport, D |
Journal | Curr Opin Cell Biol |
Volume | 44 |
Pagination | 110-116 |
Date Published | 2017 02 |
ISSN | 1879-0410 |
Keywords | Animals, Cell Polarity, Models, Biological, Morphogenesis, Signal Transduction |
Abstract | <p>Many tissues develop coordinated patterns of cell polarity that align with respect to the tissue axes. This phenomenon refers to planar cell polarity (PCP) and is controlled by multiple conserved PCP modules. A key feature of PCP proteins is their asymmetric localization within the tissue plane, whose orientation is guided by global directional cues. Here, we highlight current models and recent findings on the role of tissue-level gradients, local organizer signals, and mechanical forces in establishing the global patterns of PCP.</p> |
DOI | 10.1016/j.ceb.2016.08.002 |
Alternate Journal | Curr Opin Cell Biol |
PubMed ID | 27576155 |
PubMed Central ID | PMC5326696 |
Grant List | R01 AR066070 / AR / NIAMS NIH HHS / United States R01 AR068320 / AR / NIAMS NIH HHS / United States |