Planar cell polarity: global inputs establishing cellular asymmetry. Author Wen Aw, Danelle Devenport Publication Year 2017 Type Journal Article Abstract Many tissues develop coordinated patterns of cell polarity that align with respect to the tissue axes. This phenomenon refers to planar cell polarity (PCP) and is controlled by multiple conserved PCP modules. A key feature of PCP proteins is their asymmetric localization within the tissue plane, whose orientation is guided by global directional cues. Here, we highlight current models and recent findings on the role of tissue-level gradients, local organizer signals, and mechanical forces in establishing the global patterns of PCP. Keywords Animals, Morphogenesis, Models, Biological, Signal Transduction, Cell Polarity Journal Curr Opin Cell Biol Volume 44 Pages 110-116 Date Published 2017 Feb ISSN Number 1879-0410 DOI 10.1016/j.ceb.2016.08.002 Alternate Journal Curr Opin Cell Biol PMCID PMC5326696 PMID 27576155 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML