Planar cell polarity: global inputs establishing cellular asymmetry.

TitlePlanar cell polarity: global inputs establishing cellular asymmetry.
Publication TypeJournal Article
Year of Publication2017
AuthorsAw, WYih, Devenport, D
JournalCurr Opin Cell Biol
Volume44
Pagination110-116
Date Published2017 02
ISSN1879-0410
KeywordsAnimals, Cell Polarity, Models, Biological, Morphogenesis, Signal Transduction
Abstract

<p>Many tissues develop coordinated patterns of cell polarity that align with respect to the tissue axes. This phenomenon refers to planar cell polarity (PCP) and is controlled by multiple conserved PCP modules. A key feature of PCP proteins is their asymmetric localization within the tissue plane, whose orientation is guided by global directional cues. Here, we highlight current models and recent findings on the role of tissue-level gradients, local organizer signals, and mechanical forces in establishing the global patterns of PCP.</p>

DOI10.1016/j.ceb.2016.08.002
Alternate JournalCurr. Opin. Cell Biol.
PubMed ID27576155
PubMed Central IDPMC5326696
Grant ListR01 AR066070 / AR / NIAMS NIH HHS / United States
R01 AR068320 / AR / NIAMS NIH HHS / United States