Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.

TitlePlanar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns.
Publication TypeJournal Article
Year of Publication2017
AuthorsCetera, M, Leybova, L, Woo, FW, Deans, M, Devenport, D
JournalDev Biol
Date Published2017 08 01
KeywordsAnimals, Body Patterning, Carrier Proteins, Cell Polarity, Frizzled Receptors, Hair Follicle, Membrane Proteins, Mice, Mice, Knockout, Morphogenesis, Nerve Tissue Proteins, Signal Transduction

<p>Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations. Strikingly, Vangl2 and Fz6 mutant follicles collectively rotate with opposing directionalities, suggesting that redundant core PCP signals contribute to their directed realignment. Consistently, global follicle alignment is not restored upon conditional ablation of both Vangl1 and Vangl2 genes. Instead, spatially distinct patterns of whorls and crosses emerge and persist even after a complete cycle of hair follicle regeneration. Thus, local refinement of hair follicles into higher order patterns can occur independently of the core PCP system, however, their global alignment with the body axes requires PCP function throughout morphogenesis, growth and regeneration.</p>

Alternate JournalDev Biol
PubMed ID28599846
PubMed Central IDPMC5549468
Grant ListR01 AR066070 / AR / NIAMS NIH HHS / United States
R01 DC013066 / DC / NIDCD NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States