Physical properties of the bacterial outer membrane.

TitlePhysical properties of the bacterial outer membrane.
Publication TypeJournal Article
Year of Publication2022
AuthorsSun, J, Rutherford, ST, Silhavy, TJ, Huang, KCasey
JournalNat Rev Microbiol
Date Published2022 Apr
KeywordsBacterial Outer Membrane, Bacterial Outer Membrane Proteins, Cell Membrane, Gram-Negative Bacteria, Permeability

<p>It has long been appreciated that the Gram-negative outer membrane acts as a permeability barrier, but recent studies have uncovered a more expansive and versatile role for the outer membrane in cellular physiology and viability. Owing to recent developments in microfluidics and microscopy, the structural, rheological and mechanical properties of the outer membrane are becoming apparent across multiple scales. In this Review, we discuss experimental and computational studies that have revealed key molecular factors and interactions that give rise to the spatial organization, limited diffusivity and stress-bearing capacity of the outer membrane. These physical properties suggest broad connections between cellular structure and physiology, and we explore future prospects for further elucidation of the implications of outer membrane construction for cellular fitness and survival.</p>

Alternate JournalNat Rev Microbiol
PubMed ID34732874
PubMed Central IDPMC8934262
Grant ListR35 GM118024 / GM / NIGMS NIH HHS / United States
RM1 GM135102 / GM / NIGMS NIH HHS / United States