Peroxisome Plasticity at the Virus-Host Interface.

TitlePeroxisome Plasticity at the Virus-Host Interface.
Publication TypeJournal Article
Year of Publication2019
AuthorsCook, KC, Moreno, JA, Beltran, PMJean, Cristea, IM
JournalTrends Microbiol
Volume27
Issue11
Pagination906-914
Date Published2019 11
ISSN1878-4380
KeywordsAnimals, Biological Evolution, Host Microbial Interactions, Humans, Peroxisomes, Plant Viruses, Viral Tropism, Virus Diseases, Virus Replication
Abstract

<p>Peroxisomes are multifunctional organelles with roles in cellular metabolism, cytotoxicity, and signaling. The plastic nature of these organelles allows them to respond to diverse biological processes, such as virus infections, by remodeling their biogenesis, morphology, and composition to enhance specific functions. During virus infections in humans, peroxisomes act as important immune signaling organelles, aiding the host by orchestrating antiviral signaling. However, more recently it was discovered that peroxisomes can also benefit the virus, facilitating virus-host interactions that rewire peroxisomes to support cellular processes for virus replication and spread. Here, we describe recent studies that uncovered this double-edged character of peroxisomes during infection, highlighting mechanisms that viruses have coevolved to take advantage of peroxisome plasticity. We also provide a perspective for future studies by comparing the established roles of peroxisomes in plant infections and discussing the promise of virology studies as a venue to reveal the uncharted biology of peroxisomes.</p>

DOI10.1016/j.tim.2019.06.006
Alternate JournalTrends Microbiol
PubMed ID31331665
PubMed Central IDPMC6857447
Grant ListR01 GM114141 / GM / NIGMS NIH HHS / United States
T32 GM007388 / GM / NIGMS NIH HHS / United States