A PBX/MEIS Complex Balances Reproduction and Somatic Resilience.

TitleA PBX/MEIS Complex Balances Reproduction and Somatic Resilience.
Publication TypeJournal Article
Year of Publication2019
AuthorsHeimbucher, T, Murphy, CT
JournalDev Cell
Volume49
Issue2
Pagination157-158
Date Published2019 04 22
ISSN1878-1551
KeywordsAnimals, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Homeodomain Proteins, Transcription Factors
Abstract

<p>Resource reallocation to metabolic processes promoting reproduction is critical for the survival of a species and therefore is tightly regulated. In this issue of Developmental Cell, Dowen (2019) finds that a PBX/MEIS homeodomain transcription factor complex controls a transcriptional network that balances reproduction versus longevity and somatic maintenance.</p>

DOI10.1016/j.devcel.2019.04.005
Alternate JournalDev Cell
PubMed ID31014476
PubMed Central IDPMC7452753
Grant ListR56 AG047344 / AG / NIA NIH HHS / United States