Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae.

TitleParallel quorum sensing systems converge to regulate virulence in Vibrio cholerae.
Publication TypeJournal Article
Year of Publication2002
AuthorsMiller, MB, Skorupski, K, Lenz, DH, Taylor, RK, Bassler, BL
JournalCell
Volume110
Issue3
Pagination303-14
Date Published2002 Aug 09
ISSN0092-8674
Keywords4-Butyrolactone, Bacterial Proteins, Cell Communication, DNA, Bacterial, Gene Expression Regulation, Bacterial, Luminescent Proteins, Phosphoproteins, Repressor Proteins, Signal Transduction, Trans-Activators, Vibrio cholerae, Virulence
Abstract

<p>The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence.</p>

Alternate JournalCell
PubMed ID12176318
Grant ListAI39654 / AI / NIAID NIH HHS / United States
AI41558 / AI / NIAID NIH HHS / United States