Title | Outer Membrane Protein Insertion by the β-barrel Assembly Machine. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Ricci, DP, Silhavy, TJ |
Journal | EcoSal Plus |
Volume | 8 |
Issue | 2 |
Date Published | 2019 Mar |
ISSN | 2324-6200 |
Keywords | Bacterial Outer Membrane Proteins, Escherichia coli, Escherichia coli Proteins, Gram-Negative Bacteria, Protein Folding, Protein Transport |
Abstract | <p>Like all outer membrane (OM) constituents, integral OM β-barrel proteins in Gram-negative bacteria are synthesized in the cytoplasm and trafficked to the OM, where they are locally assembled into the growing OM by the ubiquitous β-barrel assembly machine (Bam). While the identities and structures of all essential and accessory Bam components have been determined, the basic mechanism of Bam-assisted OM protein integration remains elusive. Here we review mechanistic analyses of OM β-barrel protein folding and Bam dynamics and summarize recent insights that inform a general model for OM protein recognition and assembly by the Bam complex.</p> |
DOI | 10.1128/ecosalplus.ESP-0035-2018 |
Alternate Journal | EcoSal Plus |
PubMed ID | 30869065 |
PubMed Central ID | PMC6419762 |
Grant List | R35 GM118024 / GM / NIGMS NIH HHS / United States |