Title | An oscillatory circuit underlying the detection of disruptions in temporally-periodic patterns. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Gao, J, Schwartz, G, Berry, MJ, Holmes, P |
Journal | Network |
Volume | 20 |
Issue | 2 |
Pagination | 106-35 |
Date Published | 2009 |
ISSN | 1361-6536 |
Keywords | Animals, Models, Neurological, Photic Stimulation, Retinal Bipolar Cells, Retinal Ganglion Cells |
Abstract | <p>Neurons in diverse brain areas can respond to the interruption of a regular stimulus pattern by firing bursts of spikes. Here we describe a simple model, which permits such responses to periodic stimuli over a substantial frequency range. Focusing on the omitted stimulus response (OSR) in isolated retinas subjected to periodic patterns of dark flashes, we develop a biophysically-realistic model which accounts for resonances in ON bipolar cells. The bipolar cell terminal contains an LRC oscillator whose inductance is modulated by a transient calcium concentration, thus adjusting its resonant frequency to approximately match that of the stimulus. The model reproduces ganglion cell outputs, which sum the ON and OFF bipolar pathways, and it responds to omitted flashes with approximately constant latencies, as observed experimentally.</p> |
DOI | 10.1080/09548980902991705 |
Alternate Journal | Network |
PubMed ID | 19568983 |
PubMed Central ID | PMC2752637 |
Grant List | R01 EY017934 / EY / NEI NIH HHS / United States R56 EY014196 / EY / NEI NIH HHS / United States P50 MH062196 / MH / NIMH NIH HHS / United States R01 EY014196 / EY / NEI NIH HHS / United States P50 MH062196-09 / MH / NIMH NIH HHS / United States |