Optogenetics and biosensors set the stage for metabolic cybergenetics.

TitleOptogenetics and biosensors set the stage for metabolic cybergenetics.
Publication TypeJournal Article
Year of Publication2020
AuthorsCarrasco-López, C, García-Echauri, SA, Kichuk, T, Avalos, JL
JournalCurr Opin Biotechnol
Volume65
Pagination296-309
Date Published2020 10
ISSN1879-0429
KeywordsBiosensing Techniques, Fermentation, Metabolic Engineering, Metabolic Networks and Pathways, Optogenetics
Abstract

<p>Cybergenetic systems use computer interfaces to enable feed-back controls over biological processes in real time. The complex and dynamic nature of cellular metabolism makes cybergenetics attractive for controlling engineered metabolic pathways in microbial fermentations. Cybergenetics would not only create new avenues of research into cellular metabolism, it would also enable unprecedented strategies for pathway optimization and bioreactor operation and automation. Implementation of metabolic cybergenetics, however, will require new capabilities from actuators, biosensors, and control algorithms. The recent application of optogenetics in metabolic engineering, the expanding role of genetically encoded biosensors in strain development, and continued progress in control algorithms for biological processes suggest that this technology will become available in the not so distant future.</p>

DOI10.1016/j.copbio.2020.07.012
Alternate JournalCurr Opin Biotechnol
PubMed ID32932048