Title | Oncohistones: Exposing the nuances and vulnerabilities of epigenetic regulation. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Mitchener, MM, Muir, TW |
Journal | Mol Cell |
Volume | 82 |
Issue | 16 |
Pagination | 2925-2938 |
Date Published | 2022 Aug 18 |
ISSN | 1097-4164 |
Keywords | Chromatin, Epigenesis, Genetic, Histones, Humans, Mutation, Neoplasms |
Abstract | <p>Work over the last decade has uncovered a new layer of epigenetic dysregulation. It is now appreciated that somatic missense mutations in histones, the packaging agents of genomic DNA, are often associated with human pathologies, especially cancer. Although some of these "oncohistone" mutations are thought to be key drivers of cancer, the impacts of the majority of them on disease onset and progression remain to be elucidated. Here, we survey this rapidly expanding research field with particular emphasis on how histone mutants, even at low dosage, can corrupt chromatin states. This work is unveiling the remarkable intricacies of epigenetic control mechanisms. Throughout, we highlight how studies of oncohistones have leveraged, and in some cases fueled, the advances in our ability to manipulate and interrogate chromatin at the molecular level.</p> |
DOI | 10.1016/j.molcel.2022.07.008 |
Alternate Journal | Mol Cell |
PubMed ID | 35985302 |
PubMed Central ID | PMC9482148 |
Grant List | R01 GM086868 / GM / NIGMS NIH HHS / United States R01 CA259365 / CA / NCI NIH HHS / United States P01 CA196539 / CA / NCI NIH HHS / United States F32 GM131632 / GM / NIGMS NIH HHS / United States R37 GM086868 / GM / NIGMS NIH HHS / United States |