Oleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction

TitleOleic Acid Protects Caenorhabditis Mothers From Mating-Induced Death and the Cost of Reproduction
Publication TypeJournal Article
Year of Publication2021
AuthorsChoi, LS, Shi, C, Ashraf, J, Sohrabi, S, Murphy, CT
JournalFront Cell Dev Biol
Volume9
Pagination690373
Date Published2021
ISSN2296-634X
Abstract

Reproduction comes at a cost, including accelerated death. Previous studies of the interconnections between reproduction, lifespan, and fat metabolism in C. elegans were predominantly performed in low-reproduction conditions. To understand how increased reproduction affects lifespan and fat metabolism, we examined mated worms; we find that a Δ9 desaturase, FAT-7, is significantly up-regulated. Dietary supplementation of oleic acid (OA), the immediate downstream product of FAT-7 activity, restores fat storage and completely rescues mating-induced death, while other fatty acids cannot. OA-mediated lifespan restoration is also observed in C. elegans mutants suffering increased death from short-term mating, and in mated C. remanei females, indicating a conserved role of oleic acid in post-mating lifespan regulation. Our results suggest that increased reproduction can be uncoupled from the costs of reproduction from somatic longevity regulation if provided with the limiting lipid, oleic acid.

DOI10.3389/fcell.2021.690373
Alternate JournalFront Cell Dev Biol
PubMed ID34179018
PubMed Central IDPMC8226236