Nuclear antiviral innate responses at the intersection of DNA sensing and DNA repair. Author Joshua Justice, Ileana Cristea Publication Year 2022 Type Journal Article Abstract The coevolution of vertebrate and mammalian hosts with DNA viruses has driven the ability of host cells to distinguish viral from cellular DNA in the nucleus to induce intrinsic immune responses. Concomitant viral mechanisms have arisen to inhibit DNA sensing. At this virus-host interface, emerging evidence links cytokine responses and cellular homeostasis pathways, particularly the DNA damage response (DDR). Nuclear DNA sensors, such as the interferon (IFN)-γ inducible protein 16 (IFI16), functionally intersect with the DDR regulators ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK). Here, we discuss accumulating knowledge for the DDR-innate immunity signaling axis. Through the lens of this infection-driven signaling axis, we present host and viral molecular strategies acquired to regulate autoinflammation and antiviral responses. Keywords Animals, DNA, Mammals, DNA Damage, Immunity, Innate, Interferons, DNA Repair, Antiviral Agents, DNA-Activated Protein Kinase Journal Trends Microbiol Volume 30 Issue 11 Pages 1056-1071 Date Published 2022 Nov ISSN Number 1878-4380 DOI 10.1016/j.tim.2022.05.004 Alternate Journal Trends Microbiol PMCID PMC9560981 PMID 35641341 PubMedPubMed CentralGoogle ScholarBibTeXEndNote X3 XML