Normal cognitive and social development require posterior cerebellar activity.

TitleNormal cognitive and social development require posterior cerebellar activity.
Publication TypeJournal Article
Year of Publication2018
AuthorsBadura, A, Verpeut, JL, Metzger, JW, Pereira, TD, Pisano, TJ, Deverett, B, Bakshinskaya, DE, Wang, SS-H
JournalElife
Volume7
Date Published2018 Sep 18
ISSN2050-084X
Abstract

Cognitive and social capacities require postnatal experience, yet the pathways by which experience guides development are unknown. Here we show that the normal development of motor and nonmotor capacities requires cerebellar activity. Using chemogenetic perturbation of molecular layer interneurons to attenuate cerebellar output in mice, we found that activity of posterior regions in juvenile life modulates adult expression of eyeblink conditioning (paravermal lobule VI, crus I), reversal learning (lobule VI), persistive behavior and novelty-seeking (lobule VII), and social preference (crus I/II). Perturbation in adult life altered only a subset of phenotypes. Both adult and juvenile disruption left gait metrics largely unaffected. Contributions to phenotypes increased with the amount of lobule inactivated. Using an anterograde transsynaptic tracer, we found that posterior cerebellum made strong connections with prelimbic, orbitofrontal, and anterior cingulate cortex. These findings provide anatomical substrates for the clinical observation that cerebellar injury increases the risk of autism.

DOI10.7554/eLife.36401
Alternate JournalElife
PubMed ID30226467
Grant ListInnovational Research Incentives Scheme VENI (NWO ZonMw) / / Nederlandse Organisatie voor Wetenschappelijk Onderzoek /
R01 NS045193 / / National Institutes of Health /
CBIR16FEL010 / / New Jersey Commission on Brain Injury Research /
Graduate Research Fellowship DGE-1148900 / / National Science Foundation /
R01 MH115750 / / National Institutes of Health /
F30 MH115577 / / National Institutes of Health /
F31 NS089303 / / National Institutes of Health /