A new cap for kinetochore fibre minus ends.

Author
Sabine Petry, Ronald Vale
Publication Year
2011

Type

Journal Article
Abstract

In mitotic spindles, each sister chromatid is directly attached to a spindle pole through microtubule bundles known as kinetochore fibres. Microspherule protein 1 (MCRS1) is now shown to support spindle assembly by localizing to the minus ends of kinetochore fibres and protecting them from depolymerization.

Keywords
Animals, RNA-Binding Proteins, Nuclear Proteins, Humans, Spindle Apparatus, Chromosome Segregation, Kinetochores, ran GTP-Binding Protein
Journal
Nat Cell Biol
Volume
13
Issue
12
Pages
1389-91
Date Published
2011 Nov 13
ISSN Number
1476-4679
DOI
10.1038/ncb2387
Alternate Journal
Nat Cell Biol
PMCID
PMC3532025
PMID
22081093