Neural underpinnings of the evidence accumulator.

TitleNeural underpinnings of the evidence accumulator.
Publication TypeJournal Article
Year of Publication2016
AuthorsBrody, CD, Hanks, TD
JournalCurr Opin Neurobiol
Date Published2016 Apr
KeywordsAnimals, Choice Behavior, Models, Animal, Neurophysiology, Rodentia

<p>Gradual accumulation of evidence favoring one or another choice is considered a core component of many different types of decisions, and has been the subject of many neurophysiological studies in non-human primates. But its neural circuit mechanisms remain mysterious. Investigating it in rodents has recently become possible, facilitating perturbation experiments to delineate the relevant causal circuit, as well as the application of other tools more readily available in rodents. In addition, advances in stimulus design and analysis have aided studying the relevant neural encoding. In complement to ongoing non-human primate studies, these newly available model systems and tools place the field at an exciting time that suggests that the dynamical circuit mechanisms underlying accumulation of evidence could soon be revealed.</p>

Alternate JournalCurr Opin Neurobiol
PubMed ID26878969
PubMed Central IDPMC5777584
Grant ListF32 MH098572 / MH / NIMH NIH HHS / United States
R01 MH108358 / MH / NIMH NIH HHS / United States