Natural selection interacts with recombination to shape the evolution of hybrid genomes.

TitleNatural selection interacts with recombination to shape the evolution of hybrid genomes.
Publication TypeJournal Article
Year of Publication2018
AuthorsSchumer, M, Xu, C, Powell, DL, Durvasula, A, Skov, L, Holland, C, Blazier, JC, Sankararaman, S, Andolfatto, P, Rosenthal, GG, Przeworski, M
JournalScience
Volume360
Issue6389
Pagination656-660
Date Published2018 May 11
ISSN1095-9203
KeywordsAlleles, Animals, Chimera, Epistasis, Genetic, Evolution, Molecular, Fishes, Hybridization, Genetic, Recombination, Genetic, Selection, Genetic
Abstract

<p>To investigate the consequences of hybridization between species, we studied three replicate hybrid populations that formed naturally between two swordtail fish species, estimating their fine-scale genetic map and inferring ancestry along the genomes of 690 individuals. In all three populations, ancestry from the "minor" parental species is more common in regions of high recombination and where there is linkage to fewer putative targets of selection. The same patterns are apparent in a reanalysis of human and archaic admixture. These results support models in which ancestry from the minor parental species is more likely to persist when rapidly uncoupled from alleles that are deleterious in hybrids. Our analyses further indicate that selection on swordtail hybrids stems predominantly from deleterious combinations of epistatically interacting alleles.</p>

DOI10.1126/science.aar3684
Alternate JournalScience
PubMed ID29674434
PubMed Central IDPMC6069607
Grant ListR00 GM111744 / GM / NIGMS NIH HHS / United States
R01 GM083098 / GM / NIGMS NIH HHS / United States
R35 GM125055 / GM / NIGMS NIH HHS / United States