Title | A multifaceted signal recorder of cellular experiences using Cas12a base-editing. |
Publication Type | Journal Article |
Year of Publication | 2022 |
Authors | Zhang, P, Chan, MM |
Journal | Trends Biotechnol |
Volume | 40 |
Issue | 11 |
Pagination | 1279-1281 |
Date Published | 2022 Nov |
ISSN | 1879-3096 |
Keywords | Animals, CRISPR-Cas Systems, Gene Editing, Mammals |
Abstract | <p>Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.</p> |
DOI | 10.1016/j.tibtech.2022.07.009 |
Alternate Journal | Trends Biotechnol |
PubMed ID | 35933268 |