A multifaceted signal recorder of cellular experiences using Cas12a base-editing.

TitleA multifaceted signal recorder of cellular experiences using Cas12a base-editing.
Publication TypeJournal Article
Year of Publication2022
AuthorsZhang, P, Chan, MM
JournalTrends Biotechnol
Volume40
Issue11
Pagination1279-1281
Date Published2022 Nov
ISSN1879-3096
KeywordsAnimals, CRISPR-Cas Systems, Gene Editing, Mammals
Abstract

<p>Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.</p>

DOI10.1016/j.tibtech.2022.07.009
Alternate JournalTrends Biotechnol
PubMed ID35933268