| Title | A multifaceted signal recorder of cellular experiences using Cas12a base-editing. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Zhang, P, Chan, MM |
| Journal | Trends Biotechnol |
| Volume | 40 |
| Issue | 11 |
| Pagination | 1279-1281 |
| Date Published | 2022 Nov |
| ISSN | 1879-3096 |
| Keywords | Animals, CRISPR-Cas Systems, Gene Editing, Mammals |
| Abstract | <p>Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.</p> |
| DOI | 10.1016/j.tibtech.2022.07.009 |
| Alternate Journal | Trends Biotechnol |
| PubMed ID | 35933268 |
